MersV1, Main, Exploration, bibRecord, 003829

Pneumococcus Activation of the 5-Lipoxygenase Pathway and Production of Glycoproteins in the Middle Ear of Rats

Identifieur interne : 003829 ( Main/Exploration ); précédent : 003828; suivant : 003830

Pneumococcus Activation of the 5-Lipoxygenase Pathway and Production of Glycoproteins in the Middle Ear of Rats

Auteurs : Jizhen Lin [États-Unis] ; Andrea Vambutas ; Atsushi Haruta ; Michael M. Paparella ; G. Scott Giebink ; Youngki Kim

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 1999.

RBID : ISTEX:A273B07EEFB526D39051C048231FC9375E4ED8B2

Abstract

Pneumococcal otitis media is associated with the production of potent inflammatory mediators (leukotrienes), but the mechanism by which pneumococcus induces production of leukotrienes in the middle ear is poorly understood. In this study, up-regulation of 2 genes that govern the lipoxygenase pathway, cPLA2 and 5-LOX, was observed in rats following inoculation of pneumococcus into the middle ear cavity. Expression of cPLA2 was low, and 5-LOX gene expression was not detected in control animals. Up-regulation of cPLA2 and 5-LOX in middle ear epithelial cells was accompanied by an increase of high-molecular-weight glycoproteins in middle ear fluid and cells. These findings suggest that pneumococcus activates the lipoxygenase pathway by up-regulating expression of the cPLA2 and 5-LOX genes. This, in turn, may stimulate synthesis and secretion of high-molecular-weight glycoproteins that facilitate production of fluid in the middle ear cleft.

Url:

https://api.istex.fr/ark:/67375/HXZ-LBDQJV7M-M/fulltext.pdf

DOI: 10.1086/314714

Affiliations:

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Le document en format XML

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<front><div type="abstract">Pneumococcal otitis media is associated with the production of potent inflammatory mediators (leukotrienes), but the mechanism by which pneumococcus induces production of leukotrienes in the middle ear is poorly understood. In this study, up-regulation of 2 genes that govern the lipoxygenase pathway, cPLA2 and 5-LOX, was observed in rats following inoculation of pneumococcus into the middle ear cavity. Expression of cPLA2 was low, and 5-LOX gene expression was not detected in control animals. Up-regulation of cPLA2 and 5-LOX in middle ear epithelial cells was accompanied by an increase of high-molecular-weight glycoproteins in middle ear fluid and cells. These findings suggest that pneumococcus activates the lipoxygenase pathway by up-regulating expression of the cPLA2 and 5-LOX genes. This, in turn, may stimulate synthesis and secretion of high-molecular-weight glycoproteins that facilitate production of fluid in the middle ear cleft.</div>
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Pneumococcus Activation of the 5-Lipoxygenase Pathway and Production of Glycoproteins in the Middle Ear of Rats

Pneumococcus Activation of the 5-Lipoxygenase Pathway and Production of Glycoproteins in the Middle Ear of Rats

Source :

Abstract

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Le document en format XML

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